Express Pharma

Opinion: Flavour encapsulation redefined

Indu Bhushan, CEO and Director - STEERLife highlights the power of hot melt extrusion in food and pharmaceutical applications

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Humans are naturally drawn to sensory pleasures, often reaching for vibrant, juicy fruits and richly flavoured foods that offer a satisfying taste experience. Flavours play a pivotal role in creating these experiences, making food both appealing and memorable. Think of the zest of fresh-cut citrus or the comforting aroma of vanilla in a morning latte—flavours like these rely on volatile compounds that are remarkably sensitive to factors like pH, heat, light, and chemical interactions. Protecting these delicate compounds from degradation until consumption is essential, particularly in industries like food and pharmaceuticals where flavour consistency, stability, and quality are paramount. Flavour encapsulation offers a powerful solution to preserve these complex sensory profiles, enabling the creation of products that not only taste fresh but also deliver stability and cost-effectiveness.

The art and science of flavour encapsulation

Flavour encapsulation refers to various techniques used to stabilise and deliver liquid flavours in a functional form, protecting them from environmental stressors. Manufacturing techniques include spray drying, melt extrusion, melt injection, spray chilling, lipid coating, liposome formation, complex coacervation, absorption (plating), adsorption, complexation, and co-crystallization.

Encapsulation begins with two fundamental elements. First, the flavour itself—composed of numerous volatile organic compounds—is detectable by the human olfactory system even in minute amounts. The second component is the co-solvent, which standardises the flavour’s active ingredients to a specific strength. Common co-solvents include hydrophilic agents like propylene glycol and ethanol for fruit flavours and fractionated coconut oil or medium-chain triglycerides for more hydrophobic flavours.

Flavour encapsulation typically uses carbohydrates like sugar and maltodextrins as the wall material, forming a glassy matrix that ensures powder stability, product texture, and flavour retention. This matrix offers long-term preservation and release control, vital in both food and pharmaceutical applications.

Hot melt extrusion in flavour encapsulation

The Hot Melt Extrusion (HME) process has emerged as an effective encapsulation technique. In this process, a co-rotating twin-screw extruder melts carbohydrate carriers under pressure, which are then expelled to form shapes like sheets, ropes, or threads. The extruded material rapidly cools to a glassy state, creating a stable matrix that can be conveyed, milled, sifted, and packaged in a continuous cycle.

Flavours are added at the feed port or directly to the molten mass, depending on the desired outcome. Notably, the HME process enables the creation of larger flavour particles that provide visual impact, particularly beneficial in hard candies and personal-care tablets. The larger encapsulated particles dissolve slowly and demonstrate controlled-release properties in products like bake mixes, batters, and fried snacks. The process can also incorporate higher-molecular-weight food polymers, enhancing the stability and controlled-release properties of the flavours.

Future opportunities in flavour encapsulation

The growing demand for better flavour delivery, taste, and cost-effectiveness presents ongoing challenges to flavour manufacturers. While some advanced controlled-release technologies from the pharmaceutical industry might be adaptable, the regulatory and cost-benefit distinctions between food and pharma create unique challenges.

To meet these demands, the food industry must leverage advances in materials science, polymer science, physical chemistry, and flavour chemistry. The potential for HME to lead future innovations in flavour encapsulation is vast, with opportunities for customisation, controlled release, and improved stability in various food and pharmaceutical products.

Addressing limitations and challenges

While HME presents numerous advantages, some limitations require attention to optimise its potential:

  1. Temperature sensitivity: HME requires high temperatures to melt the components, which may compromise certain flavours and active pharmaceutical ingredients (APIs) sensitive to heat. Careful adjustments are essential to minimise degradation.
  2. Regulatory compliance: Gaining regulatory approvals for HME in pharmaceutical applications is challenging due to its relatively new application in drug manufacturing. Regulatory compliance for complex formulations remains a hurdle.
  3. Equipment costs: HME equipment, like twin-screw extruders, is costly to purchase and maintain. This investment barrier may limit accessibility to large-scale manufacturers or constrain small-scale operations to early-stage development.

The way forward: Toward sustainable flavour encapsulation

Addressing the encapsulation challenges in pharmaceuticals and food is essential, as flavour stability and solubility significantly impact consumer experience and therapeutic efficacy. HME offers a solvent-free, versatile solution that enhances stability and bioavailability while accommodating complex compounds.

However, maximising the potential of HME will require overcoming the current obstacles—particularly temperature sensitivity, regulatory concerns, and high equipment costs—through research, innovation, and technology advancements. Meeting these challenges will allow manufacturers to create flavours and pharmaceuticals that align with consumers’ sensory and health needs.

Conclusion

Flavor encapsulation using HME is paving the way for innovative applications in food and pharmaceuticals. By ensuring careful handling of flavours and materials, addressing regulatory standards, and expanding research into sustainable encapsulation techniques, the industry can harness the full potential of HME. Collaboration between food science, chemistry, and engineering will further drive breakthroughs, creating products that not only satisfy sensory demands but also support a more sustainable and health-conscious future.

 

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