In this video:
Dr Girish Jain, Pharma Consultant
Topic: In vitro and in vivo correlation: General considerations
Key Highlights:
+ In vitro In vivo correlation (IVIVC) shall be demonstrated consistently with two or more formulations with different release rates resulting in corresponding differences in In vivo absorption profile
+ IVIVCs are developed in fasted state unless the drug is not tolerated in fasted state
+ In vitro dissolution methodology should adequately discriminate among formulations
+ The same dissolution method should be used for different formulations
Great Post! Thanks for sharing the knowledge and keep up the good work.