Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for indications with under-served needs in neurology and cardiology, has received an 1 million euro grant to support the Translate-MS-Repair project.
The French ‘Agence Nationale de la Recherche’ (ANR) awarded the second successive grant to Trophos to target Multiple Sclerosis (MS) with olesoxime. The funding will be provided under the Recherches Partenariales et Innovation Biomedicale 2012 programme. Translate-MS-Repair will be a 24-month project and will include a Phase Ib/IIa clinical study of olesoxime, Trophos’ lead compound, to target neurodegeneration that underlies long-term progressive disability in multiple sclerosis.
The project will be operated by a consortium spearheaded by Trophos including leading experts in Marseille (AP-HM/CNRS and CEMEREM-CRMBM), Rennes (CHU de Rennes and INRIA VISAGES) and Reims (CHU de Reims).
The clinical trial, which will be performed in three centres in France, will be led by Dr Jean Pelletier AP-HM/CNRS-CEMEREM. The clinical trial is designed to demonstrate the compatibility of olesoxime as a co-medication with existing treatments, the most frequent being beta interferon. The study will also assess the feasibility of non-conventional magnetic resonance imaging procedures in a multicenter trial. The clinical trial is designed to result in future large-scale clinical trials to assess efficacy of olesoxime to prevent progressive disability in MS patients.
Rebecca Pruss, CSO, Trophos, “MS is the first cause of non-traumatic disability in young adults. While there are a number of effective treatments to control the relapsing inflammatory episodes, they have little effect on progressive disability in MS patients.
EP News Bureau