WHO announces plans to establish a TB Vaccine Accelerator Council

The World Health Organization (WHO) Director General Dr Tedros Adhanom Ghebreyesus yesterday announced plans to establish a new TB Vaccine Accelerator Council.

Speaking at a panel on TB at the World Economic Forum (WEF), he said that the council will facilitate the licensing and use of effective novel TB vaccines catalysing high-level alignment among funders, global agencies, governments and end users in identifying and overcoming barriers to TB vaccine development.

“One of the most important lessons from the response to the COVID-19 pandemic is that innovative health interventions can be delivered fast if they are prioritised politically and financed adequately. The challenges presented by TB and COVID-19 are different, but the ingredients that accelerate science, research and innovation are the same: urgent, up-front public investment; support from philanthropy; and engagement of the private sector and communities. We believe the TB field will benefit from similar high-level coordination,” Dr Ghebreyesus emphasised.

BCG is currently the only licensed TB vaccine. While it provides moderate efficacy in preventing severe forms of TB in infants and young children, it does not adequately protect adolescents and adults, who account for close to 90 per cent of TB transmissions globally.

A recent WHO commissioned study, an investment case for new tuberculosis (TB) vaccines estimates that over 25 years, a vaccine that is 50 per cent effective in preventing disease among adolescents and adults could avert up to 76 million new TB cases, 8.5 million deaths, 42 million courses of antibiotic treatment and $6.5 billion in costs faced by TB-affected households, especially for the poorest and the most vulnerable.

A vaccine that is 75 per cent effective could avert up to 110 million new TB cases and 12.3 million deaths. The study further suggests that every $1 invested in a 50 per cent effective vaccine could generate an economic return of $7 in terms of averted health costs and increased productivity.

Later this year, heads of states and governments will meet for a second United Nations High-Level Meeting on TB to review progress against commitments made in the 2018 political declaration. This presents an opportunity to correct setbacks in the TB response, which includes the urgent development and delivery of new TB vaccines.