Dr Girish Jain, Pharma Consultant | FDD Conclave 2022
In this video:
Dr Girish Jain, Pharma Consultant
Topic: In vitro and in vivo correlation: General considerations
Key Highlights:
+ In vitro In vivo correlation (IVIVC) shall be demonstrated consistently with two or more formulations with different release rates resulting in corresponding differences in In vivo absorption profile
+ IVIVCs are developed in fasted state unless the drug is not tolerated in fasted state
+ In vitro dissolution methodology should adequately discriminate among formulations
+ The same dissolution method should be used for different formulations
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