Express Pharma

Filtration in formulation development – Selection and validation

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Clovin Adarsh, Scientist II – Scientific and Laboratory Services (SLS), Pall Corporation, began his presentation by informing about the factors one needs to keep in mind while choosing a filter. “While selecting a filter, one needs to keep in mind the contaminants, conditions, volume and time frame,” he noted.

Next, he spoke about the size of a filter and said that sizing involves volume to be filtered, time for filtration and mode of filtration.

He further said that general considerations for process-specific validations involve critical process fluid attributes, process parameters, scientific rationale, use of products where possible and worst-case conditions.

Some of the services of the filters offered by Pall Corporation also include viability, bacterial retention, test parameters determination, compatibility, adsorption, extractables, leachables, safety and toxological assessments.

He then suggested that Pall can provide consulting and laboratory services to support customers during the entire E&L evaluation lifecycle.

In addition to it, he concluded his presentation by talking about the role the company played during the COVID-19 pandemic.

“Pall was able to develop and deploy a full manufacturing process for COVID-19 vaccine in eight weeks – an 80 per cent reduction – to dramatically reduce normal development times,” he said.

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1 Comment
  1. soundos says

    Great work. Keep it up!!!!

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