OGT and Emory Genetics Laboratory develop new molecular arrays

Oxford Gene Technology (OGT), the molecular genetics company, has expanded its range of research-validated CytoSure molecular arrays to investigate DNA copy number variation (CNV) underlying a variety of genetic disorders. Designed and optimised in collaboration with experts at Emory Genetics Laboratory (EGL; Atlanta, US), the arrays are the ideal complement to DNA sequencing, providing a particularly powerful tool for investigating the variety of aberrations underlying genetic disorders.

Comparative genomic hybridisation arrays (aCGH) are the gold-standard for CNV detection and the 60-mer oligonucleotide probes utilised by OGT’s aCGH platform have been shown to deliver superior CNV detection than alternative platforms. The expanded CytoSure molecular array portfolio enables the detection of CNV in genes associated with over 20 genetic disorders, including cardiovascular, inherited eye, intellectual disability and neuromuscular disorders, as well as a range of inherited cancers. In addition, genes covering each disorder can be combined to create bespoke custom arrays, or further customised by the addition of novel content to suit each individual research project.

For the easy extraction of meaningful results from aCGH data, all CytoSure Molecular Arrays are supplied with OGT’s class-leading CytoSure interpret software.

Utilising highly targeted, exon-focussed arrays has been shown to detect CNVs as small as 12 bp in size that were missed by targeted NGS. Whether used alone or alongside sequencing, CytoSure Molecular Arrays allow researchers to reliably investigate the role of CNV in a wide range of genetic disorders.

Contact Details:
Oxford Gene Technology
Begbroke Science Park
Begbroke Hill
Woodstock Road
Begbroke, Oxfordshire, OX5 1PF, UK
Tel: +44 (0) 1865 856826
Fax: +44 (0) 1865 848684
Email: [email protected]
Website: www.ogt.com
Twitter: @OxfordGeneTech