Signet organises technical seminars in collaboration with Shin-Etsu

Signet recently organised technical seminars in Ahmedabad and Hyderabad on 16th and 18th November, 2022, respectively. Nearly 200 attendees were there for both the locations from various pharma companies. The objective of the seminars was to highlight the applications possible with Shin-Etsu excipients, along with emphasis on certain novel technologies for solubility enhancement.

Six eminent speakers shared their expertise with the audience on various topics.

Nitin Bhusane, Director, Shin-Etsu, India, presented chemistry and applications of cellulosic polymers majorly focussing on its use in HME for solid dispersion and further processing into final dosage form. The presentation also covered a brief introduction on other approaches to formulate a solid dispersion along with case studies conducted by Shin-Etsu lab on Nifedipine and Itraconazole by HME.

Dr Padma Devarajan, Dean, Institute of Chemical Technology (Former UDCT), Mumbai, delivered a lecture on advanced third-generation solid dispersion. The case study on bioavailability enhancement of curcumin displayed a novel concept of application of solid dispersion as a coating membrane on neutral substrate.

Dr Ajmeera Ramkishan, Deputy Drug Controller of India, covered the regulations and norms on drugs and excipients specifically for the Indian market.

Manoj Bansal, Commercial Leader – MC India, Thermo Fischer, delivered a lecture on the basics of holt melt extruder. He meticulously covered the anatomy of HME and its accessories, a systematic approach towards development and optimisation of formulation, basic engineering principles used in HME and its significance in scale-up processes.

Nilesh Mahajan, Technical Manager, Shin-Etsu, India, spoke on continuous manufacturing by twin-screw granulation process using Shin-Etsu excipients. He also covered solvent-based approaches for preparing solid dispersion.

Arun D’Souza, Technical Manager, Shin-Etsu, India, comprehensively covered the application of Shin-Etsu polymers in enteric coating application via aqueous, non-aqueous and ammonia-neutralisation approaches. He also presented case studies of application of Metolose grades for sustained release formulations.

All the sessions were informative and addressed the possibilities of evaluating Shin-Etsu excipients for various applications.