UK first to approve Omicron COVID shot with Moderna nod

Britain has become the first country to approve a COVID-19 vaccine that targets both the original and Omicron variant of the virus.

The UK medicines regulator (MHRA) approved the so-called bivalent vaccine made by Moderna as a booster for adults.

The agency’s decision was based on clinical trial data that showed the booster triggered “a strong immune response” against both Omicron (BA.1) and the original 2020 virus, it said.

The MHRA also cited an exploratory analysis in which the shot was found to generate a good immune response against the currently dominant Omicron offshoots BA.4 and BA.5.

No serious safety concerns were identified with this new formulation, the agency added.

Now, approval has been secured, Britain’s Joint Committee on Vaccination and Immunization (JCVI) will advise on how the vaccine should be deployed in the country.

While the existing COVID-19 vaccines continue to provide good protection against hospitalisation and death, vaccine effectiveness has taken a hit as the virus has evolved.

“The first generation of COVID-19 vaccines being used in the UK continue to provide important protection against the disease and save lives,” June Raine, Chief Executive, MHRA, said in a statement.

“What this bivalent vaccine gives us is a sharpened tool in our armory to help protect us against this disease as the virus continues to evolve.”

European Medicines Agency (EMA) officials expect COVID variant-adapted vaccines to be approved in the European Union (EU) by September, and have signalled the regulator is open to using shots targetting the older BA.1 variant this autumn, given those specifically targetting newer subvariants are further behind in clinical development.

In contrast, the US Food and Drug Administration (FDA) has said it will seek the specific inclusion of the newer BA.4 and BA.5 offshoots of omicron in any new shots used domestically.

Apart from Moderna, partners Pfizer and BioNTech have also been testing versions of their mRNA vaccine modified to combat Omicron variants.

Meanwhile, Sanofi and GSK are working on a protein-based vaccine that targets the beta subvariant, which dominated for some time last year.

Edits by EP News Bureau